The drug colchicine was formerly used to treat gout.
Answer both in details.
The drug colchicine was formerly used to treat gout. Now, other drugs with a similar function are being considered for the treatment of cancer. What cytoskeletal component do colchicines affect, and why would drugs that target this component be effective at treating cancer? (5 )
Tetracycline is an effective antibiotic because it inhibits protein synthesis. The action mechanism is binding the 30s ribosomal subunit in bacteria, thereby preventing the docking of amino-acylated tRNA. With your knowledge of the translation process, explain how tetracycline would prevent protein synthesis. (5 s)
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ANSWER 1 Colchicine is a mitotic inhibitor. It prevents polymerisation of microtubules. Colchicine binds to tubulin which are monomers of microtubules. Colchicine binding to tubulin prevents thei.
